Vibrational molecular pathology
IR and Raman spectral imaging can distinguish between tissue types, disease types and stages, and even identify the primary tumors from spectral patterns observed in metastatic cells.
View ArticleExploiting synergies – multimodal nonlinear imaging in the biomedical sciences
Multimodal nonlinear microscopy has matured to a key imaging modality in life science and biomedicine.
View ArticleCARS microscopy on its way to clinical translation
Coherent anti-Stokes Raman scattering microscopy offers noninvasive label-free imaging, high sensitivity, and chemical specificity.
View ArticleControlling light with light
A new approach to control light with light without the need for optical nonlinearity has been suggested by a Russian-British research group.
View ArticleUltra-black silicon makes an excellent broadband absorber
A novel ultra-black broadband absorber concept based on a needle-like silicon nanostructure has been developed by Jena researchers.
View ArticleA better look into arteries
Multispectral fluorescence lifetime imaging system with ultrasound guidance could improve intravascular diagnostics and analysis of atherosclerotic lesions.
View ArticleImproved early detection of esophagus dysplasia
A novel screening approach for discriminating dysplasia from metaplasia in Barrett’s Esophagus using diffuse reflectance spectroscopy.
View ArticleCombed radio frequencies: an overview
Optical frequency comb technology for ultra-broadband radio-frequency photonics.
View ArticleCancer all-clear for nonlinear optical imaging
Dutch researchers have estimated the risk of squamous cell cancer induction in skin following nonlinear optical imaging.
View ArticleElectromagnetic absorbers: from narrow to broad
Chinese scientists have given an overview on the principle of different types of narrowband EM absorbers.
View ArticleBetter quantification of blood samples: more signal, less background
A team based in Germany develop a new method for simultaneous quantification of ZnPP and PPIX in unwashed blood samples.
View ArticleNanoparticle concentration measured acoustically
Three-dimensional optoacoustic tomography enables quantitative measurements of nanoparticle concentrations to evaluate their biodistributions in animal models.
View ArticleSERS probes from silver microneedles get under the skin
Scientists from NTU have suggested the use of metal-coated microneedles to improve below-skin Raman spectroscopy.
View ArticleMonitoring retina inflammation with Raman spectroscopy
Raman spectroscopy of the retina coupled with multivariate analysis might become a promising tool to study retina diseases in vivo.
View ArticleModeling blood capillaries to prevent shock
Monitoring of blood capillary/vessel patterns with spatially resolved diffuse reflectance spectrometry might allow for the early detection of clinical shock.
View ArticleA synergetic pairing: epifluorescent microscopy and electrophoretic microarrays
Detection of nanoparticles and DNA biomarkers at clinically relevant low levels can be achieved by combining epifluorescent microscopy with dielectrophoretic microarrays.
View ArticleMeasuring skin rejuvenation with two-photon microscopy
In vivo and non-invasive: Collagen remodeling after micro-ablative fractional laser resurfacing can be monitored by two-photon microscopy.
View ArticleMembranes under observation
Membrane nano-tomography in living cells: Label-free evanescent microscopy enables full-field and real-time tracking of membrane processes.
View ArticleNew endoscopic technique provides label-free contrast of tissue
A flexible wide-field endoscope utilising blue excitation light provides label-free contrast of tissue based on fluorescence lifetime imaging of tissue autofluorescence. Fluorescence lifetime imaging...
View ArticlePerpendicular geometry for better photoacoustic images
A new approach based on bidirectional scanning improves the imaging performance of optoacoustic imaging to quasi-isotropic transverse resolution.
View ArticleQuantifying molecular colocalization in live cell fluorescence microscopy
Toward identification and characterization of molecular interactions in living cells: Quantifying molecular colocalization in live cell fluorescence microscopy.
View ArticleTrapping and watching motile cells
A new approach enables rapid characterization of living suspension cells in 4 dimensions while they are immobilized and manipulated within optical traps.
View ArticleSimplicity is the trump card – Quick analysis of optical spectra
Based on a quick analysis of optical spectra, a practical approach for assessing the melanin and blood content of the skin was developed.
View ArticleA new paradigm – functional and nonlinear optical metasurfaces
Optical metasurfaces offer a wealth of useful functionalities. Their nonlinear effects can be enhanced with the help of metasurface engineering.
View ArticleTracking sperm with confocal laser endomicroscopy
Probe-based confocal laser endomicroscopy (pCLE) might improve the results of testicular sperm extraction while reducing traumata during surgery.
View ArticleShort, Ultrashort, Sub-Cycle Short – Towards sub-cycle optical waveforms
Coherent synthesis of pulses generated by separate sources may pave the way to sub-cycle optical waveforms.
View ArticleFor a better view into turbid media
Enhancement in imaging performance of a spectral-domain optical coherence microscope (OCM) in turbid media by incorporating an optical parametric amplifier.
View ArticleCancer diagnosis using the Raman technique
The Raman technique is on its way to be translated into clinical use. Latest developments of real-time in vivo Raman systems for cancer detection are reviewed.
View ArticleIncreased sensitivity of molecular optoacoustic imaging
Molecular optoacoustic imaging is a powerful tool for research and for diagnostics. Multiple excitation wavelengths tend to increase its sensitivity .
View ArticleQuantum Cascade Lasers
Steady progress turns multi-wavelength quantum cascade laser arrays into a powerful versatile source for next-generation spectroscopy and stand-off detection systems.
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